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Radha Karki Selected Research

Type I DNA Topoisomerases (Topoisomerase I)

5/2016A new series of 2-phenol-4-aryl-6-chlorophenyl pyridine derivatives as dual topoisomerase I/II inhibitors: Synthesis, biological evaluation and 3D-QSAR study.
7/2015Topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of dihydroxylated 2,6-diphenyl-4-aryl pyridines.
1/2015Synthesis and biological activity of 2,4-di-p-phenolyl-6-2-furanyl-pyridine as a potent topoisomerase II poison.
9/2014Synthesis, antitumor activity, and structure-activity relationship study of trihydroxylated 2,4,6-triphenyl pyridines as potent and selective topoisomerase II inhibitors.
6/2012Design, synthesis, and antitumor evaluation of 2,4,6-triaryl pyridines containing chlorophenyl and phenolic moiety.
3/2012Dihydroxylated 2,4,6-triphenyl pyridines: synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.
2/20122,4-Diaryl-5,6-dihydro-1,10-phenanthroline and 2,4-diaryl-5,6-dihydrothieno[2,3-h] quinoline derivatives for topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study.
8/2011Synthesis of 2,4-diaryl chromenopyridines and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
5/2010Synthesis, topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship study of hydroxylated 2,4-diphenyl-6-aryl pyridines.
3/2010Synthesis of 2-(thienyl-2-yl or -3-yl)-4-furyl-6-aryl pyridine derivatives and evaluation of their topoisomerase I and II inhibitory activity, cytotoxicity, and structure-activity relationship.
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Radha Karki Research Topics

Disease

15Neoplasms (Cancer)
10/2017 - 07/2007
1Breast Neoplasms (Breast Cancer)
02/2015
1Non-Hodgkin Lymphoma (Lymphosarcoma)
04/2013
1Multiple Myeloma
04/2013

Drug/Important Bio-Agent (IBA)

13Type I DNA Topoisomerases (Topoisomerase I)IBA
05/2016 - 07/2007
7Antineoplastic Agents (Antineoplastics)IBA
05/2016 - 01/2010
4pyridineIBA
05/2016 - 01/2010
2Etoposide (VP 16)FDA LinkGeneric
02/2015 - 01/2015
2PyridinesIBA
02/2012 - 05/2010
1Paclitaxel (Taxol)FDA LinkGeneric
10/2017
1ProdrugsIBA
10/2017
1Folic Acid (Vitamin M)FDA LinkGeneric
10/2017
1DNA (Deoxyribonucleic Acid)IBA
02/2015
1trioctyl phosphine oxide (TOPO)IBA
01/2015
1RetinoidsIBA
01/2014
1Proteasome InhibitorsIBA
04/2013
1Bortezomib (Velcade)FDA Link
04/2013
1Pharmaceutical PreparationsIBA
04/2013
1ElementsIBA
04/2013
1BoronIBA
04/2013
1quinolineIBA
02/2012
1Hydroxyl RadicalIBA
05/2010